The numb chin in breast cancer.
نویسندگان
چکیده
Numbness of the chin, an uncommon neurological symptom, was observed in 15 patients with cancer. Thirteen had breast cancer. This symptom usually heralded progressive involvement of the cranial nerves or cerebrum and denoted a poor prognosis in patients with a short `tumourfree interval'. The pathogenesis is commonly related to dural involvement of the Vth cranial nerve at the base of the brain, although metastasis to the mandible might sometimes be implicated. The reason for the peculiar predilection for the mandibular branch of the trigeminal nerve to be affected by breast cancer is not known.
منابع مشابه
Teaching NeuroImages: "numb chin syndrome" in a patient with breast cancer.
A51-year-old woman with breast cancer presented with progressive numbness and burning in the right lower gum and oral mucosa. Neurologic examination was normal except for reduced sensation in the right lower gum region. Inferior alveolar neuropathy from mandible metastasis was diagnosed (figures 1 and 2). “Numb chin syndrome” is characterized by decreased sensation in the chin or lower lip, ora...
متن کاملNumb Chin Syndrome in Nasopharyngeal Cancer Patients Demonstrated by Bone Scan: Report of Two Cases
Received 5/18/2006; revised 6/23/2006; accepted 6/26/2006. For correspondence or reprints contact: Ming-Hsien Lin, M.D., Department of Nuclear Medicine, Taipei City Hospital, Zhongxiao Branch. 87 Tong De Road, Nan Gang District, Taipei 115, Taiwan. Tel: (886)2-27861288 ext. 8089, Fax: (886)2-26534501, E-mail: [email protected] The numb chin syndrome (NCS), also referred to as mental neuropathy...
متن کاملNUMB negatively regulates the epithelial-mesenchymal transition of triple-negative breast cancer by antagonizing Notch signaling
Triple-negative breast cancer (TNBC), an aggressive subtype of breast cancer with higher rates of early relapse and metastasis, is frequently associated with aberrant activation of epithelial-mesenchymal transition (EMT). Nonetheless, how EMT is initiated and regulated during TNBC progression is not well understood. Here, we report that NUMB is a negative regulator of EMT in both human mammary ...
متن کاملNumb chin syndrome as the initial presentation of posttransplant lymphoproliferative disorder.
N umb chin syndrome is a sensory neuropathy caused by compromise of the mental nerve, the posterior branch of the inferior alveolar nerve, which leads to numbness or tingling in its respective distribution. Th ere is no loss of motor function, as the inferior alveolar nerve contains no motor fi bers. While associated with certain benign etiologies (1–3), the condition is increasingly reported a...
متن کاملNumb Chin Syndrome as First Symptom of Diffuse Large B-Cell Lymphoma
Numb chin syndrome is a rare sensory neuropathy of the mental nerve characterized by numbness, hypoesthesia, paraesthesia, and very rarely pain. Dental causes, especially iatrogenic ones, maxillofacial trauma, or malignant neoplasm are etiologic factors for this rare syndrome. Many malignant and metastatic neoplasms are causing this syndrome, like primary osteosarcoma, squamous cell carcinoma, ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of neurology, neurosurgery, and psychiatry
دوره 36 2 شماره
صفحات -
تاریخ انتشار 1973